The drug dupilumab helps against nasal polyps in patients with chronic sinusitis, in whom treatment with corticosteroids is not sufficient. This is shown by research that was published in the Journal of the American Medical Association..
Chronic sinusitis, an inflammation of the sinuses, occurs in the West in 12% of the population. The condition is sometimes accompanied by nasal polyps.
These polyps originate in the sinuses and block the cavities in the sinus and in the nose.
In the search for treatment for the nasal polyps, an international team of researchers tested dupilumab. Dupilumab is an antibody that proved its worth in the treatment of asthma and atopic eczema.
The scientists examined 60 adults with chronic sinusitis and nasal polyps. All patients received a nasal spray. In some cases this was done in combination with dupilumab, the others received a placebo. The study was conducted at 13 locations in the United States and Europe.
In the patients who received dupilumab, the nasal polyps were significantly smaller after 16 weeks.
The patients noticed a marked improvement in their quality of life, and reported that they could smell better, suffer less from a stuffy nose and wake up less often at night.
The drug was generally well tolerated and did not cause serious side effects, but further research is still needed.